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CS-W001157 4
Total: USD 88.00

5,6-Difluoro-1H-1,3-benzodiazol-2-amine

  • CAS No. 142356-62-5

  • Cat. No. CS-0160745
  • Purity≥97%
  • MDL No.MFCD16845540

*For research and further manufacturing use only, not for direct human use.

5,6-Difluoro-1H-1,3-benzodiazol-2-amine|CS-0160745

Structure of 142356-62-5

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General Information

  • CAS No. 142356-62-5
  • Cat. No. CS-0160745
  • Purity ≥97%
  • MDL No. MFCD16845540
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂N₃
  • Molecular Weight 169.13
  • Synonym(s) 1H-Benzimidazol-2-amine,5,6-difluoro-(9CI)
  • SMILES NC1=NC2=CC(F)=C(F)C=C2N1

Description

5,6-Difluoro-1H-1,3-benzodiazol-2-amine features a fluorinated benzodiazole core with dual electron-withdrawing substituents, enhancing its stability and enabling directed functionalization in synthetic workflows. This bench-stable compound integrates readily into pharmaceutical intermediates and bioactive scaffolds, offering improved metabolic resistance and targeted electronic modulation.

Application

5,6-Difluoro-1H-1,3-benzodiazol-2-amine serves as a versatile building block for fluorinated heterocyclic scaffolds, enabling efficient access to bioactive molecules via Pd-catalyzed cross-coupling and electrophilic substitution reactions. Its enhanced stability and favorable functional group tolerance facilitate streamlined synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.4233
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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