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CS-W001157 4
Total: USD 88.00

5-Fluoro-1H-benzo[d]imidazol-2-amine

  • CAS No. 30486-73-8

  • Cat. No. CS-0187800
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-1H-benzo[d]imidazol-2-amine|CS-0187800

Structure of 30486-73-8

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General Information

  • CAS No. 30486-73-8
  • Cat. No. CS-0187800
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FN₃
  • Molecular Weight 151.14
  • Synonym(s) 6-fluoro-1H-benzimidazol-2-amine
  • SMILES FC=1C=CC=2NC(=NC2C1)N

Description

5-Fluoro-1H-benzo[d]imidazol-2-amine features a fluorinated benzimidazole core with a primary amine at the 2-position, offering enhanced electron density and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for targeted kinase inhibitors and CNS-active compounds.

Application

5-Fluoro-1H-benzo[d]imidazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its fluorinated aromatic core and amine functionality provide excellent reactivity in Suzuki-Miyaura couplings, Buchwald-Hartwig aminations, and electrophilic substitutions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.2842
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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