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CS-W001157 4
Total: USD 88.00

3-Amino-isonicotinic acid ethyl ester

  • CAS No. 14208-83-4

  • Cat. No. CS-D0762
  • Purity≥98%
  • MDL No.MFCD03788270

*For research and further manufacturing use only, not for direct human use.

3-Amino-isonicotinic acid ethyl ester|CS-D0762

Structure of 14208-83-4

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General Information

  • CAS No. 14208-83-4
  • Cat. No. CS-D0762
  • Purity ≥98%
  • MDL No. MFCD03788270
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂O₂
  • Molecular Weight 166.18
  • Synonym(s) Ethyl 3-Aminopyridine-4-carboxylate
  • SMILES O=C(OCC)C1=CC=NC=C1N

Description

3-Amino-isonicotinic acid ethyl ester features a para-amino group flanked by a pyridine ring and an ester functionality, enabling direct integration into heterocyclic scaffolds. This bench-stable derivative serves as a key building block for bioactive molecules in medicinal chemistry and ligand design.

Application

3-Amino-isonicotinic acid ethyl ester serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds. Its ortho-amino and ester functionalities offer orthogonal reactivity for sequential functionalization, including amidation, Suzuki coupling, and cyclization reactions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for multi-step synthesis and API intermediate development.

Synthesis

  • Route1
    • null|null
      64-17-5
    • In-stock
      3-Aminoisonicotinic acid|CS-D0792
      7579-20-6
    • ~63%
    • In-stock
      3-Amino-isonicotinic acid ethyl ester|CS-D0762
      14208-83-4

    References

    • Chen, Qingping; Deady, Leslie W. Australian Journal of Chemistry, 1993 , vol. 46, # 7 p. 987 - 993
  • Route2

    References

    • US5250548 A1, ; US 5250548 A
  • Route3

    References

    • Bioorganic and Medicinal Chemistry, , vol. 9, # 8 p. 2061 - 2071

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   0.8405
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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