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Structure of 1418007-47-2
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(E)-3-(Thiazol-5-yl)acrylic acid features a conjugated enoic acid system linked to a thiazole heterocycle, delivering enhanced electron-withdrawing character and planar geometry. This structural motif enables direct incorporation into Michael acceptor frameworks, facilitating efficient coupling in cross-coupling and cycloaddition reactions under standard conditions.
(E)-3-(Thiazol-5-yl)acrylic acid serves as a versatile building block for the synthesis of thiazole-containing pharmaceuticals and bioactive heterocycles. Its conjugated enoic acid functionality enables efficient Michael additions, Diels-Alder reactions, and palladium-catalyzed couplings. The compound exhibits good bench stability and facilitates straightforward purification via recrystallization, making it well-suited for scalable medicinal chemistry campaigns and API intermediate development.
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Lot numbers can be found on the outside label of a product: