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Fmoc-N-(tert-butyloxycarbonylmethyl)glycine

  • CAS No. 141743-16-0

  • Cat. No. CS-0154832
  • Purity≥98%
  • MDL No.MFCD05663767

*For research and further manufacturing use only, not for direct human use.

Fmoc-N-(tert-butyloxycarbonylmethyl)glycine|CS-0154832

Structure of 141743-16-0

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General Information

  • CAS No. 141743-16-0
  • Cat. No. CS-0154832
  • Purity ≥98%
  • MDL No. MFCD05663767
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₅NO₆
  • Molecular Weight 411.45
  • Synonym(s) Glycine, N-(carboxymethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester
  • SMILES CC(C)(C)OC(=O)CN(CC(=O)O)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C31

Description

Fmoc-N-(tert-butyloxycarbonylmethyl)glycine features a dual-protecting group architecture, combining the Fmoc moiety for N-terminal protection with a tert-butyl ester for side-chain modulation. This bifunctional design enables selective coupling in peptide synthesis while maintaining stability under standard deprotection conditions.

Application

Fmoc-N-(tert-butyloxycarbonylmethyl)glycine serves as a versatile di-functional building block in peptide synthesis, enabling the incorporation of both Fmoc-protected amines and acid-labile Boc-type side chains. Its structure facilitates orthogonal protection strategies in multi-step syntheses, particularly for peptides requiring selective deprotection sequences. The molecule exhibits good bench stability and simplifies purification due to its solubility profile and well-defined cleavage behavior under standard acidic conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   93.14
  • LogP   3.6638
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   6

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