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CS-W001157 4
Total: USD 88.00

3-Bromo-5-methoxyquinoline

  • CAS No. 1416438-38-4

  • Cat. No. CS-0144185
  • Purity≥98%
  • MDL No.MFCD22690582

*For research and further manufacturing use only, not for direct human use.

3-Bromo-5-methoxyquinoline|CS-0144185

Structure of 1416438-38-4

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General Information

  • CAS No. 1416438-38-4
  • Cat. No. CS-0144185
  • Purity ≥98%
  • MDL No. MFCD22690582
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈BrNO
  • Molecular Weight 238.08
  • Synonym(s) None
  • SMILES COC1=C2C=C(Br)C=NC2=CC=C1

Description

3-Bromo-5-methoxyquinoline is a halogenated quinoline derivative featuring a bromine atom at the 3-position and a methoxy group at the 5-position. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions, serving as a key building block for pharmaceutical intermediates and advanced organic materials.

Application

3-Bromo-5-methoxyquinoline serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig transformations. The bromine moiety provides high reactivity for C–C and C–N bond formation, while the methoxy group enhances solubility and modulates electronic properties. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex quinoline-based scaffolds in API development and functional molecular design.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   3.0059
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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