(4-Bromo-6-methylpyridin-2-yl)methanol

Name: (4-Bromo-6-methylpyridin-2-yl)methanol
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CAS No. 448906-60-3
Cat. No. CS-0140620
Purity≥98%
MDL No.MFCD07374946

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(4-Bromo-6-methylpyridin-2-yl)methanol|CS-0140620

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General Information

CAS No. 448906-60-3
Cat. No. CS-0140620
Purity ≥98%
MDL No. MFCD07374946
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈BrNO
Molecular Weight 202.05
Synonym(s) 4-Bromo-6-methylpyridine-2-methanol
SMILES OCC1=NC(C)=CC(Br)=C1

Description

(4-Bromo-6-methylpyridin-2-yl)methanol features a brominated pyridine core with a methyl group at the 6-position and a reactive hydroxymethyl functionality. This bench-stable, moisture-tolerant reagent integrates readily into cross-coupling workflows and serves as a key intermediate in the synthesis of bioactive heterocycles and functionalized pharmaceutical scaffolds.

Application

(4-Bromo-6-methylpyridin-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via its bromo and hydroxymethyl groups. The bromine facilitates Suzuki-Miyaura and Stille couplings, while the alcohol functions as a handle for derivatization or protection. Its bench-stable nature and compatibility with diverse reaction conditions make it suitable for modular synthesis of pyridine-based scaffolds in drug discovery workflows.

Safety Information

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Computational Chemistry Data

TPSA 33.12
LogP 1.64482
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(4-Bromo-6-methylpyridin-2-yl)methanol

CAS No. 448906-60-3

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