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CS-W001157 4
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2-Oxa-5,8-diazaspiro[3.5]nonane dihydrochloride

  • CAS No. 1416323-26-6

  • Cat. No. CS-0030166
  • Purity≥97%
  • MDL No.MFCD22570257

*For research and further manufacturing use only, not for direct human use.

2-Oxa-5,8-diazaspiro[3.5]nonane dihydrochloride|CS-0030166

Structure of 1416323-26-6

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General Information

  • CAS No. 1416323-26-6
  • Cat. No. CS-0030166
  • Purity ≥97%
  • MDL No. MFCD22570257
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄Cl₂N₂O
  • Molecular Weight 201.09
  • Synonym(s) None
  • SMILES [H]Cl.[H]Cl.C12(CNCCN2)COC1

Description

This spirocyclic dihydrochloride features a rigid, electron-deficient heterocyclic core that enhances binding affinity in medicinal chemistry applications. The paired nitrogen atoms enable efficient protonation and salt formation, improving solubility and stability under standard conditions.

Application

2-Oxa-5,8-diazaspiro[3.5]nonane dihydrochloride serves as a versatile, bench-stable heterocyclic building block for medicinal chemistry and catalytic synthesis. Its spirocyclic architecture provides defined stereochemistry and enhanced metabolic stability, while the protonated amine centers enable efficient salt formation and improved solubility. The molecule facilitates orthogonal functionalization and functions effectively in transition metal-catalyzed couplings, making it well-suited for constructing complex nitrogen-containing scaffolds in drug discovery campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.29
  • LogP   -0.2082
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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