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CS-W001157 4
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2-(Pyridin-2-yloxy)benzaldehyde

  • CAS No. 141580-71-4

  • Cat. No. CS-0074744
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Pyridin-2-yloxy)benzaldehyde|CS-0074744

Structure of 141580-71-4

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General Information

  • CAS No. 141580-71-4
  • Cat. No. CS-0074744
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉NO₂
  • Molecular Weight 199.21
  • Synonym(s) 2-(PYRID-2-YLOXY)BENZALDEHYDE
  • SMILES O=CC1=CC=CC=C1OC2=CC=CC=N2

Description

This pyridin-2-yloxy-substituted benzaldehyde features a strategically positioned aldehyde group flanked by electron-rich aromatic systems, enabling direct integration into Suzuki-Miyaura coupling and Ullmann-type cross-coupling reactions. The ortho-arranged heterocyclic oxygen enhances chelation potential in transition metal complexes, while maintaining bench-stable handling under standard conditions.

Application

2-(Pyridin-2-yloxy)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its ortho-heterocyclic motif provides enhanced rigidity and polarity, while the aldehyde functionality facilitates imine formation, reductive amination, and coupling reactions. Bench-stable and readily purified by column chromatography, it exhibits broad functional group tolerance in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.6864
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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