Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde

  • CAS No. 141103-93-7

  • Cat. No. CS-0187036
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde|CS-0187036

Structure of 141103-93-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 141103-93-7
  • Cat. No. CS-0187036
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁NO₂
  • Molecular Weight 177.20
  • Synonym(s) 4-Methyl-3,4-Dihydro-2H-1,4-Benzoxazine-7-Carbaldehyde
  • SMILES CN1CCOC2=C1C=CC(=C2)C=O

Description

4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde features a rigid, electron-rich heterocyclic scaffold with a pendant aldehyde group. This functionalized platform enables direct incorporation into bioactive molecules and serves as a key intermediate in medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Application

4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to biologically relevant scaffolds. The aldehyde functionality facilitates coupling reactions, reductive amination, and imine-based transformations, while the fused oxazine ring system provides structural rigidity and favorable pharmacophore geometry. Bench-stable and compatible with standard purification methods, it functions effectively in multi-step syntheses of potential kinase inhibitors and CNS-targeted compounds.

Synthesis

  • Route1
    • null|null
      68-12-2
    • In-stock
      7-Bromo-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-0097830
      154264-95-6
    • ~99%
    • In-stock
      4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde|CS-0187036
      141103-93-7

    References

    • MERCK SHARP and DOHME CORP.; KOZLOWSKI, Joseph A.; ROSENBLUM, Stuart B.; COBURN, Craig A.; SHANKAR, Bandarpalle, B.; ANILKUMAR, G., Nair; CHEN, Lei; DWYER, Michael, P.; JIANG, Yueheng; KEERTIKAR, Kartik, M.; LAVEY, Brian, J.; SELYUTIN, Oleg, B.; TONG, Ling; WONG, Michael; YANG, De-Yi; YU, Wensheng; ZHOU, Guowei; WU, Hao; HU, Bin; ZHONG, Bin; SUN, Fei; JI, Tao; SHEN, Changmao; RIZVI, Razia; ZENG, Qingbei Patent: WO2012/41014 A1, 2012 ; Location in patent: Page/Page column 236-237 ;
  • Route2
    • In-stock
      4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-0312948
      77901-22-5
    • null|null
      68-12-2
    • ~76%
    • In-stock
      4-Methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carbaldehyde|CS-0187036
      141103-93-7

    References

    • Kotha, Sambasivarao; Bindra, Vandana; Kuki, Atsuo Heterocycles, 1994 , vol. 38, # 1 p. 5 - 8
  • Route3

    References

    • Kotha, Sambasivarao; Kuki, Atsuo Journal of the Chemical Society, Chemical Communications, 1992 , # 5 p. 404 - 406

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   29.54
  • LogP   1.3277
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 141103-93-7 sigma141103-93-7 manufacturer141103-93-7 price141103-93-7 structure141103-93-7 SDSbuy 141103-93-7141103-93-7 supplier141103-93-7 uses141103-93-7 molecular weightprice of 141103-93-7141103-93-7 chemical name formula of 141103-93-7
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label