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trans-3-(Methylsulfonyl)cyclobutanamine hydrochloride

  • CAS No. 1408075-97-7

  • Cat. No. CS-0045553
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

trans-3-(Methylsulfonyl)cyclobutanamine hydrochloride|CS-0045553

Structure of 1408075-97-7

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General Information

  • CAS No. 1408075-97-7
  • Cat. No. CS-0045553
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO₂S
  • Molecular Weight 185.67
  • Synonym(s) trans-3-MethylsulfonylcyclobutylaMine hydrochloride
  • SMILES N[C@H]1C[C@H](S(=O)(C)=O)C1.[H]Cl

Description

trans-3-(Methylsulfonyl)cyclobutanamine hydrochloride is a bench-stable, moisture-tolerant amine derivative featuring a rigid cyclobutane scaffold. The methylsulfonyl group imparts high polarity and solubility, while the hydrochloride salt ensures enhanced handling and crystallinity. This compound integrates readily into medicinal chemistry libraries for targeted bioactive molecule synthesis.

Application

trans-3-(Methylsulfonyl)cyclobutanamine hydrochloride serves as a versatile, bench-stable building block for medicinal chemistry and process development. Its constrained cyclobutane scaffold imparts conformational rigidity, while the methylsulfonyl group provides excellent solubility and metabolic stability. The amine functionality enables straightforward derivatization via reductive amination, amidation, or coupling reactions, facilitating rapid access to diverse heterocyclic and bioactive scaffolds in drug discovery campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   60.16
  • LogP   -0.0575
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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