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(4S,4'S)-2,2'-(1-Phenylpropane-2,2-diyl)bis(4-phenyl-4,5-dihydrooxazole) (S)-BnPh-SaBOX

  • CAS No. 1404433-37-9

  • Cat. No. CS-0035152
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4S,4'S)-2,2'-(1-Phenylpropane-2,2-diyl)bis(4-phenyl-4,5-dihydrooxazole) (S)-BnPh-SaBOX|CS-0035152

Structure of 1404433-37-9

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General Information

  • CAS No. 1404433-37-9
  • Cat. No. CS-0035152
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₇H₂₆N₂O₂
  • Molecular Weight 410.51
  • Synonym(s) (S)-BnPh-SaBOX
  • SMILES CC(C1=N[C@@H](C2=CC=CC=C2)CO1)(C3=N[C@@H](C4=CC=CC=C4)CO3)CC5=CC=CC=C5

Description

(S,S)-2-Bn-Sabox-Ph is a chiral bis(oxazoline) ligand featuring two benzyl-protected hydroxyl groups and a phenyl-substituted backbone. This configuration enables high enantioselectivity in transition metal-catalyzed asymmetric reactions, particularly in copper-mediated additions. The protected hydroxyls enhance stability and simplify handling under standard bench conditions.

Application

(S,S)-2-Bn-Sabox-Ph serves as a robust chiral auxiliary in asymmetric synthesis, enabling stereoselective C–C bond formation through well-established enolate chemistry. Its benzyl-protected scaffold offers excellent bench stability, facile purification, and compatibility with diverse reaction conditions, making it ideal for iterative synthetic sequences in medicinal chemistry and natural product synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.18
  • LogP   5.5754
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   6

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