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CS-W001157 4
Total: USD 88.00

t-Boc-N-amido-PEG5-Tos

  • CAS No. 1404111-69-8

  • Cat. No. CS-0528834
  • Purity≥96%
  • MDL No.MFCD34596623

*For research and further manufacturing use only, not for direct human use.

t-Boc-N-amido-PEG5-Tos|CS-0528834

Structure of 1404111-69-8

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General Information

  • CAS No. 1404111-69-8
  • Cat. No. CS-0528834
  • Purity ≥96%
  • MDL No. MFCD34596623
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₃₇NO₉S
  • Molecular Weight 491.60
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NCCOCCOCCOCCOCCOS(=O)(C1=CC=C(C)C=C1)=O

Description

t-Boc-N-amido-PEG5-Tos features a hydrophilic PEG5 spacer flanked by a stable t-Boc-protected amine and a tosyl leaving group, enabling efficient conjugation in peptide and biomolecule engineering. This derivative integrates seamlessly into modular synthesis workflows, offering enhanced solubility and controlled reactivity under standard conditions.

Application

t-Boc-N-amido-PEG5-Tos serves as a versatile, bench-stable linker for peptide and oligonucleotide conjugation, enabling efficient attachment of amine-functionalized biomolecules via orthogonal tosylate displacement. The PEG5 spacer provides solubility and reduced aggregation, while the t-Boc group offers reliable N-terminal protection compatible with standard deprotection protocols. This reagent facilitates clean coupling reactions with minimal side-product formation, making it well-suited for modular synthesis of complex bioconjugates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   118.62
  • LogP   2.29142
  • H_Acceptors   9
  • H_Donors   1
  • Rotatable_Bonds   17

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