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CS-W001157 4
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6-Chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine

  • CAS No. 1403899-44-4

  • Cat. No. CS-0187202
  • Molecule weight182.65
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine|CS-0187202

Structure of 1403899-44-4

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General Information

  • CAS No. 1403899-44-4
  • Cat. No. CS-0187202
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁ClN₂
  • Molecular Weight 182.65
  • Synonym(s) None
  • SMILES CC1(C)CNC2=CC(=NC=C21)Cl

Description

6-Chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine is a sterically hindered heterocyclic scaffold featuring a chlorine substituent at the 6-position and two methyl groups at the 3-position. This electron-deficient pyrrolopyridine core enables direct functionalization in transition-metal-catalyzed couplings and serves as a robust building block for bioactive compound synthesis.

Application

6-Chloro-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted heterocyclic scaffolds. The chloro group facilitates palladium-catalyzed cross-coupling reactions, while the dimethyl-substituted pyrrolidine ring enhances metabolic stability and modulates solubility. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for iterative synthesis campaigns in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   2.4381
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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