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CS-W001157 4
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3-(Hydroxymethyl)-1H-pyrazole-5-carboxylic acid

  • CAS No. 1401555-38-1

  • Cat. No. CS-0157311
  • Purity≥97%
  • MDL No.MFCD16619746

*For research and further manufacturing use only, not for direct human use.

3-(Hydroxymethyl)-1H-pyrazole-5-carboxylic acid|CS-0157311

Structure of 1401555-38-1

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General Information

  • CAS No. 1401555-38-1
  • Cat. No. CS-0157311
  • Purity ≥97%
  • MDL No. MFCD16619746
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O₃
  • Molecular Weight 142.11
  • Synonym(s) None
  • SMILES C1=C(CO)NN=C1C(=O)O

Description

3-(Hydroxymethyl)-1H-pyrazole-5-carboxylic acid features a pyrazole core functionalized with a carboxylic acid and hydroxymethyl group, enabling direct conjugation or derivatization in synthetic workflows. The molecule combines polar functionality with aromatic stability, supporting applications in medicinal chemistry and molecular scaffold development.

Application

3-(Hydroxymethyl)-1H-pyrazole-5-carboxylic acid serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling direct functionalization at the pyrazole core. The hydroxymethyl group facilitates oxidation to carboxylic acid or derivatization via Mitsunobu conditions, while the carboxylic acid supports amide coupling and salt formation. Its stability under standard bench handling and compatibility with common protecting group strategies make it well-suited for multi-step synthetic sequences in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   86.21
  • LogP   -0.3998
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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