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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic acid

  • CAS No. 139551-74-9

  • Cat. No. CS-W007051
  • Molecule weight367.44
  • Purity≥95%
  • MDL No.MFCD00671389

*For research and further manufacturing use only, not for direct human use.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic acid|CS-W007051

Structure of 139551-74-9

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General Information

  • CAS No. 139551-74-9
  • Cat. No. CS-W007051
  • Purity ≥95%
  • MDL No. MFCD00671389
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₅NO₄
  • Molecular Weight 367.44
  • Synonym(s) N-ALPHA-(9-FLUOROENYLMETHOXYCARBONYL)-GAMMA-METHYL-L-LEUCINE
  • SMILES CC(C)(C[C@@H](C(O)=O)NC(OCC1C2=C(C=CC=C2)C3=C1C=CC=C3)=O)C

Description

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic acid is a chiral, bench-stable amino acid derivative featuring a sterically hindered side chain and a fluorenylmethoxycarbonyl (Fmoc) protecting group. This combination enables reliable incorporation into peptide synthesis workflows while maintaining high chemical integrity under standard conditions.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-dimethylpentanoic acid serves as a robust chiral building block in peptide synthesis, offering high stereoselectivity and stability under standard coupling conditions. The Fmoc group enables efficient deprotection with mild base, while the bulky 4,4-dimethylpentanoyl side chain minimizes racemization and enhances solubility. Its compatibility with diverse coupling reagents and ease of purification make it ideal for solid-phase and solution-phase workflows in medicinal chemistry and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   4.4145
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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