Fmoc-Val-Ala-PAB-OH

Name: Fmoc-Val-Ala-PAB-OH
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CAS No. 1394238-91-5
Cat. No. CS-0102865
Molecule weight515.60
Purity≥97%
MDL No.MFCD28557282

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1394238-91-5
Cat. No. CS-0102865
Purity ≥97%
MDL No. MFCD28557282
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₀H₃₃N₃O₅
Molecular Weight 515.60
Synonym(s) None
SMILES OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O

Description

Fmoc-Val-Ala-PAB-OH is a specialized peptide building block featuring a p-aminobenzyl (PAB) linker for cleavage under mild conditions. This design enables efficient conjugation in antibody-drug conjugates and solid-phase synthesis, combining orthogonal deprotection with high stability during coupling steps.

Application

Fmoc-Val-Ala-PAB-OH serves as a versatile building block for peptide conjugation, enabling efficient solid-phase synthesis and bioconjugation workflows. The Fmoc group ensures orthogonal protection for primary amines, while the PAB-OH linker provides a stable yet cleavable attachment point for payloads such as drugs or dyes. This compound exhibits excellent bench stability, facilitates straightforward purification, and supports high-yielding coupling reactions in standard peptide chemistry protocols.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 116.76
LogP 4.1854
H_Acceptors 5
H_Donors 4
Rotatable_Bonds 9

Other Classifications

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker Cleavable Linkers

Life Science Linker Fmoc PEG

Life Science Linker Peptide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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Fmoc-Val-Ala-PAB-OH

CAS No. 1394238-91-5

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