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2-Aminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

  • CAS No. 1394003-86-1

  • Cat. No. CS-0047324
  • Molecule weight178.15
  • Purity≥97%
  • MDL No.MFCD22543886

*For research and further manufacturing use only, not for direct human use.

2-Aminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid|CS-0047324

Structure of 1394003-86-1

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General Information

  • CAS No. 1394003-86-1
  • Cat. No. CS-0047324
  • Purity ≥97%
  • MDL No. MFCD22543886
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₄O₂
  • Molecular Weight 178.15
  • Synonym(s) IPI-549 INTERMEDIATE
  • SMILES NC1=NN2C(N=CC=C2)=C1C(O)=O

Description

This heterocyclic scaffold integrates a pyrazolo[1,5-a]pyrimidine core with complementary amine and carboxylic acid functionalities, enabling direct conjugation in medicinal chemistry. The electron-deficient ring system facilitates selective interactions in target binding studies, while the carboxylic acid group supports derivatization via amidation or esterification under standard conditions.

Application

2-Aminopyrazolo[1,5-a]pyrimidine-3-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science applications. Its fused pyrazolo-pyrimidine core provides robust scaffold stability and enables efficient functionalization at both the amino and carboxylic acid positions. The molecule facilitates direct coupling reactions, supports diverse derivatization via amide and ester formation, and exhibits favorable solubility and purification characteristics in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   93.51
  • LogP   0.0097
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   1

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