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CS-W001157 4
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6-Bromo-3-chloropyrazin-2-amine

  • CAS No. 1082843-72-8

  • Cat. No. CS-D0842
  • Purity≥97%
  • MDL No.MFCD13193368

*For research and further manufacturing use only, not for direct human use.

6-Bromo-3-chloropyrazin-2-amine|CS-D0842

Structure of 1082843-72-8

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General Information

  • CAS No. 1082843-72-8
  • Cat. No. CS-D0842
  • Purity ≥97%
  • MDL No. MFCD13193368
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃BrClN₃
  • Molecular Weight 208.44
  • Synonym(s) 2-Amino-3-chloro-6-bromopyrazine
  • SMILES NC1=NC(Br)=CN=C1Cl

Description

6-Bromo-3-chloropyrazin-2-amine features a dual halogenated pyrazine core, enabling efficient cross-coupling and functionalization in medicinal chemistry. The electron-deficient heterocycle integrates readily into bioactive scaffolds, while the bromo and chloro substituents offer orthogonal reactivity for sequential derivatization under standard conditions.

Application

6-Bromo-3-chloropyrazin-2-amine serves as a versatile building block for the synthesis of heterocyclic scaffolds in medicinal chemistry and agrochemical research. Its orthogonal halogen functionality enables selective cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig couplings, facilitating rapid diversification of pyrazine cores. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it ideal for scalable, high-yield transformations in multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.4747
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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