8-(Trifluoromethyl)chroman-4-amine hydrochloride

Name: 8-(Trifluoromethyl)chroman-4-amine hydrochloride
Brand: ChemScene
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CAS No. 1392212-91-7
Cat. No. CS-0160467
Purity≥97%
MDL No.MFCD08544298

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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8-(Trifluoromethyl)chroman-4-amine hydrochloride|CS-0160467

Structure of 1392212-91-7

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General Information

CAS No. 1392212-91-7
Cat. No. CS-0160467
Purity ≥97%
MDL No. MFCD08544298
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₁ClF₃NO
Molecular Weight 253.65
Synonym(s) None
SMILES NC1CCOC2=C1C=CC=C2C(F)(F)F.[H]Cl

Description

8-(Trifluoromethyl)chroman-4-amine hydrochloride features a trifluoromethyl group at the 8-position of a chroman scaffold, imparting enhanced electron-withdrawing character and metabolic stability. The amine functionality enables facile derivatization, while the hydrochloride salt ensures high solubility and crystalline handling. This compound serves as a key building block for bioactive molecules in medicinal chemistry, particularly in kinase inhibitor and CNS-targeted drug discovery.

Application

8-(Trifluoromethyl)chroman-4-amine hydrochloride serves as a versatile building block for medicinal chemistry, enabling the synthesis of chroman-based scaffolds with enhanced metabolic stability and lipophilicity. The trifluoromethyl group imparts strong electron-withdrawing character and improved membrane permeability, while the amine functionality facilitates downstream derivatization via coupling reactions. Bench-stable and readily purified by recrystallization, it functions effectively in standard amide bond formation, reductive amination, and heterocycle functionalization protocols common in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 35.25
LogP 2.9095
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Key Words

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8-(Trifluoromethyl)chroman-4-amine hydrochloride

CAS No. 1392212-91-7

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