tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate

Name: tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate
Brand: ChemScene
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CAS No. 1389264-32-7
Cat. No. CS-0047980
Purity≥97%
MDL No.MFCD22415185

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate|CS-0047980

Structure of 1389264-32-7

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General Information

CAS No. 1389264-32-7
Cat. No. CS-0047980
Purity ≥97%
MDL No. MFCD22415185
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₄ClN₃O₂
Molecular Weight None
Synonym(s) 4-(Boc-aMinoMethyl)-6-chloropyriMidine
SMILES CC(C)(C)OC(=O)NCC1=NC=NC(Cl)=C1

Description

tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate is a bench-stable, moisture-tolerant building block featuring a chloropyrimidine core and a protected amine handle. This carbamate integrates seamlessly into medicinal chemistry campaigns, enabling direct coupling to nucleophiles or selective deprotection under mild acidic conditions. The para-chloro substitution enhances electrophilic reactivity for downstream functionalization.

Application

tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate serves as a versatile building block in medicinal chemistry, enabling the introduction of a chloropyrimidine moiety with orthogonal protection. The tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. It reacts efficiently in nucleophilic substitution and coupling reactions, supporting the construction of complex heterocyclic scaffolds relevant to kinase inhibitors and antiviral agents.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 64.11
LogP 2.1547
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

1389264-32-7 sigma1389264-32-7 manufacturer1389264-32-7 price1389264-32-7 structure1389264-32-7 SDSbuy 1389264-32-71389264-32-7 supplier1389264-32-7 uses1389264-32-7 molecular weightprice of 1389264-32-71389264-32-7 chemical name formula of 1389264-32-7

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tert-Butyl N-[(6-chloropyrimidin-4-yl)methyl]carbamate

CAS No. 1389264-32-7

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