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CS-W001157 4
Total: USD 88.00

Ethyl 3-bromo-2,2-dimethylpropanoate

  • CAS No. 2843-18-7

  • Cat. No. CS-0140566
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 3-bromo-2,2-dimethylpropanoate|CS-0140566

Structure of 2843-18-7

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General Information

  • CAS No. 2843-18-7
  • Cat. No. CS-0140566
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃BrO₂
  • Molecular Weight 209.08
  • Synonym(s) Brom-pivalinsaeure-aethylester
  • SMILES O=C(OCC)C(C)(C)CBr

Description

Ethyl 3-bromo-2,2-dimethylpropanoate is a sterically hindered bromoester featuring a quaternary carbon center, enabling selective alkylation reactions under mild conditions. This bench-stable reagent integrates readily into synthetic sequences requiring constrained electrophilic sites, particularly in the construction of densely functionalized building blocks for medicinal chemistry and natural product synthesis.

Application

Ethyl 3-bromo-2,2-dimethylpropanoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to sterically hindered alkylated scaffolds. Its α-bromination facilitates nucleophilic substitution reactions with high regioselectivity, while the ester functionality supports subsequent transformations such as hydrolysis or reduction. The tert-butyl-like steric environment enhances stability and simplifies purification, making it well-suited for iterative synthesis and scale-up in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.9706
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

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