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CS-W001157 4
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6-Oxa-1-azaspiro[3.3]heptane hemioxalate

  • CAS No. 1380571-72-1

  • Cat. No. CS-W018669
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Oxa-1-azaspiro[3.3]heptane hemioxalate|CS-W018669

Structure of 1380571-72-1

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General Information

  • CAS No. 1380571-72-1
  • Cat. No. CS-W018669
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₀N₂O₆
  • Molecular Weight 288.30
  • Synonym(s) 6-oxa-1-azaspiro[3.3]heptane,oxalic acid
  • SMILES O=C(O)C(O)=O.N1CCC12COC2.N3CCC34COC4

Description

6-Oxa-1-azaspiro[3.3]heptane hemioxalate is a bench-stable, moisture-tolerant heterocyclic scaffold featuring a fused spirocyclic core with embedded oxygen and nitrogen atoms. This rigid, electron-deficient framework integrates seamlessly into synthetic sequences requiring constrained geometry and enhanced solubility in polar media.

Application

6-Oxa-1-azaspiro[3.3]heptane hemioxalate serves as a stable, bench-friendly building block for the synthesis of bioactive heterocycles, particularly in medicinal chemistry campaigns targeting CNS-penetrant scaffolds. Its spirocyclic core provides conformational rigidity and enhanced metabolic stability, while the oxalate salt improves solubility and handling. The molecule functions effectively in standard coupling reactions and facilitates rapid access to substituted piperidinone derivatives via straightforward functionalization pathways.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   117.12
  • LogP   -1.347
  • H_Acceptors   6
  • H_Donors   4
  • Rotatable_Bonds   0

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