6'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one

Name: 6'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1378865-57-6
Cat. No. CS-W020501
Purity≥95%
MDL No.MFCD19703307

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one|CS-W020501

Structure of 1378865-57-6

Size

Price

Quantity

* Please select Quantity before adding items.

Description

6'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one features a rigid spirocyclic scaffold integrating a brominated cyclopropane with an indolinone core. This architecture imparts unique steric and electronic properties, enabling selective functionalization in synthetic sequences. The bromine atom serves as a high-reactivity handle for cross-coupling transformations, while the spiro configuration enhances structural rigidity and metabolic stability.

Application

6'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one serves as a versatile building block for the synthesis of spirocyclic indoline scaffolds prevalent in medicinal chemistry. The bromine at the 6' position enables palladium-catalyzed cross-coupling reactions, facilitating C–C bond formation under mild conditions. Its spirocyclic architecture confers rigidity and enhanced metabolic stability, while the ketone functionality offers opportunities for derivatization via nucleophilic addition or enolization. Bench-stable and readily purified by column chromatography, it functions effectively in multi-step syntheses of complex heterocycles and bioactive molecules.

General Information

CAS No. 1378865-57-6
Cat. No. CS-W020501
Purity ≥95%
MDL No. MFCD19703307
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₈BrNO
Molecular Weight 238.08
Synonym(s) 6'-Bromo-1'H-spiro[cyclopropane-1,3'-indole]-2'-one
SMILES Brc1ccc2c(NC(=O)C22CC2)c1

Computational Chemistry Data

TPSA 29.1
LogP 2.4328
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Building Blocks Skeleton Spirol Rings compounds

Key Words

1378865-57-6 sigma1378865-57-6 manufacturer1378865-57-6 price1378865-57-6 structure1378865-57-6 SDSbuy 1378865-57-61378865-57-6 supplier1378865-57-6 uses1378865-57-6 molecular weightprice of 1378865-57-61378865-57-6 chemical name formula of 1378865-57-6

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

6'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one

CAS No. 1378865-57-6

Recommended Products