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CS-W001157 4
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3-(Difluoromethyl)pyrrolidine hydrochloride

  • CAS No. 1376176-56-5

  • Cat. No. CS-0051691
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Difluoromethyl)pyrrolidine hydrochloride|CS-0051691

Structure of 1376176-56-5

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General Information

  • CAS No. 1376176-56-5
  • Cat. No. CS-0051691
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₀ClF₂N
  • Molecular Weight 157.59
  • Synonym(s) 3-(DIFLUOROMETHYL)PYRROLIDINE HCL
  • SMILES Cl.FC(F)C1CCNC1

Description

3-(Difluoromethyl)pyrrolidine hydrochloride delivers a unique difluoromethyl group attached to a pyrrolidine scaffold, enabling enhanced metabolic stability and membrane permeability in bioactive molecules. This bench-stable salt form facilitates straightforward handling and integration into synthetic workflows.

Application

3-(Difluoromethyl)pyrrolidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group into bioactive molecules. Its stability under standard reaction conditions and compatibility with common functional groups facilitate efficient synthesis of fluorinated analogs. The hydrochloride salt enhances solubility and handling, supporting reliable use in coupling reactions, nucleophilic substitutions, and heterocycle elaboration for drug discovery applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.2828
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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