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tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate

  • CAS No. 1376099-80-7

  • Cat. No. CS-0196723
  • Molecule weight215.29
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate|CS-0196723

Structure of 1376099-80-7

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General Information

  • CAS No. 1376099-80-7
  • Cat. No. CS-0196723
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₁N₃O₂
  • Molecular Weight 215.29
  • Synonym(s) TERT-BUTYL3-(AMINOMETHYL)PIPERAZINE-1-CARBOXYLATE(WX191429)
  • SMILES CC(C)(C)OC(=O)N1CCNC(CN)C1

Description

tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate features a piperazine core functionalized with a primary amine and a tert-butyl carbamate group, enabling orthogonal protection strategies in peptide and medicinal chemistry. The amine side chain supports conjugation workflows, while the robust tert-butyl ester facilitates selective deprotection under mild acidic conditions. This derivative delivers enhanced solubility and stability in synthetic sequences involving complex heterocyclic scaffolds.

Application

tert-Butyl 3-(aminomethyl)piperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperazine-based scaffolds. The tert-butyl carbamate group provides excellent stability and ease of purification, while the primary amine facilitates straightforward functionalization via reductive amination, acylation, or coupling reactions. Its compatibility with standard synthetic workflows makes it a practical choice for constructing complex heterocyclic systems and drug candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   67.59
  • LogP   0.154
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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