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CS-W001157 4
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7-Bromo-3-methylquinoline

  • CAS No. 1375108-41-0

  • Cat. No. CS-0196722
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-3-methylquinoline|CS-0196722

Structure of 1375108-41-0

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General Information

  • CAS No. 1375108-41-0
  • Cat. No. CS-0196722
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈BrN
  • Molecular Weight 222.08
  • Synonym(s) None
  • SMILES CC1=CC2=C(C=C(C=C2)Br)N=C1

Description

7-Bromo-3-methylquinoline is a halogenated quinoline derivative featuring a bromine atom at the 7-position and a methyl group at the 3-position. This electron-deficient heterocycle serves as a key scaffold in synthetic medicinal chemistry, enabling efficient coupling reactions via palladium catalysis. The strategic substitution pattern enhances metabolic stability and modulates lipophilicity for drug discovery applications.

Application

7-Bromo-3-methylquinoline serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The bromine at the C7 position enables reliable Suzuki, Stille, or Negishi coupling for C–C bond formation, while the methyl group at C3 provides a site for further functionalization. Its stability under standard reaction conditions and compatibility with diverse catalyst systems make it a practical choice for constructing complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.30572
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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