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CS-W001157 4
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5-Chloro-2-(difluoromethyl)pyridine

  • CAS No. 1374659-32-1

  • Cat. No. CS-0463435
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-(difluoromethyl)pyridine|CS-0463435

Structure of 1374659-32-1

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General Information

  • CAS No. 1374659-32-1
  • Cat. No. CS-0463435
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₂N
  • Molecular Weight 163.55
  • Synonym(s) None
  • SMILES C1=CC(=NC=C1Cl)C(F)F

Description

5-Chloro-2-(difluoromethyl)pyridine features a strategically positioned difluoromethyl group that enhances metabolic stability and modulates electronic properties. This electron-deficient pyridine scaffold supports efficient coupling reactions, enabling rapid access to bioactive heterocycles in medicinal chemistry. The molecule exhibits robust bench stability and compatibility with standard synthetic protocols.

Application

5-Chloro-2-(difluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group at the pyridine 2-position. The chloro substituent facilitates subsequent cross-coupling reactions, while the difluoromethyl moiety imparts enhanced metabolic stability and modulated lipophilicity. This compound exhibits excellent bench stability and compatibility with standard reaction conditions, facilitating efficient synthesis of fluorinated heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H227-H301-H315-H319-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.6726
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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