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CS-W001157 4
Total: USD 88.00

(S,S)-Me-BI-DIME

  • CAS No. 1373432-11-1

  • Cat. No. CS-0087679
  • Purity≥95%
  • MDL No.MFCD31707596

*For research and further manufacturing use only, not for direct human use.

(S,S)-Me-BI-DIME|CS-0087679

Structure of 1373432-11-1

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General Information

  • CAS No. 1373432-11-1
  • Cat. No. CS-0087679
  • Purity ≥95%
  • MDL No. MFCD31707596
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₅O₃P
  • Molecular Weight None
  • Synonym(s) (2S,3S)-3-(tert-butyl)-4-(2, 6-dimethoxyphenyl)-2-met hyl-2,3-dihydrobenzo[d][1, 3]oxaphosphole
  • SMILES COC(C=CC=C1OC)=C1C2=C([P@](C(C)(C)C)[C@@H](C)O3)C3=CC=C2

Description

(S,S)-Me-BI-DIME is a chiral bis(oxazoline) ligand featuring two methyl-substituted oxazoline rings, designed for asymmetric catalysis. This bench-stable, moisture-tolerant scaffold delivers high enantioselectivity in transition metal-catalyzed reactions, particularly in copper-mediated conjugate additions and cycloadditions. Its rigid, electron-rich architecture enables precise stereocontrol through well-defined coordination geometry.

Application

(S,S)-Me-BI-DIME serves as a robust chiral ligand in asymmetric catalysis, enabling high enantioselectivity in transition-metal-catalyzed transformations. Its bis-imine architecture provides excellent stereocontrol and bench stability, facilitating efficient synthesis of chiral building blocks. The methylated backbone enhances solubility and functional group tolerance, making it well-suited for scalable applications in medicinal chemistry and fine chemical synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   5.0149
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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