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CS-W001157 4
Total: USD 88.00

2-Bromoimidazo[2,1-b][1,3,4]thiadiazole-6-carboxylic acid

  • CAS No. 1373253-24-7

  • Cat. No. CS-0018932
  • Purity≥96%
  • MDL No.MFCD13193514
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Bromoimidazo[2,1-b][1,3,4]thiadiazole-6-carboxylic acid|CS-0018932

Structure of 1373253-24-7

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Description

This imidazothiadiazole carboxylic acid features a brominated heterocyclic core with enhanced reactivity at the 2-position, enabling direct coupling in C–H functionalization and cross-coupling protocols. The electron-deficient scaffold supports stable incorporation into bioactive molecules, while the carboxylic acid group facilitates conjugation or salt formation under mild conditions.

Application

2-Bromoimidazo[2,1-b][1,3,4]thiadiazole-6-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient construction of bioactive scaffolds. The bromo group facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid functionality supports derivatization via amide bond formation or esterification. Its stability under standard bench conditions and compatibility with diverse functional groups make it a practical choice for medicinal chemistry campaigns and API intermediate development.

General Information

  • CAS No. 1373253-24-7
  • Cat. No. CS-0018932
  • Purity ≥96%
  • MDL No. MFCD13193514
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrN₃O₂S
  • Molecular Weight 248.06
  • Synonym(s) None
  • SMILES O=C(C1=CN2C(SC(Br)=N2)=N1)O

Computational Chemistry Data

  • TPSA   67.49
  • LogP   1.2515
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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