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CS-W001157 4
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6-(Trifluoromethyl)imidazo[1,2-a]pyrazine-2-carboxylic acid

  • CAS No. 1372197-49-3

  • Cat. No. CS-0097627
  • Molecule weight231.13
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)imidazo[1,2-a]pyrazine-2-carboxylic acid|CS-0097627

Structure of 1372197-49-3

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General Information

  • CAS No. 1372197-49-3
  • Cat. No. CS-0097627
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄F₃N₃O₂
  • Molecular Weight 231.13
  • Synonym(s) None
  • SMILES O=C(C1=CN2C(C=NC(C(F)(F)F)=C2)=N1)O

Description

6-(Trifluoromethyl)imidazo[1,2-a]pyrazine-2-carboxylic acid features a fused heterocyclic core bearing a trifluoromethyl group at the 6-position and a carboxylic acid functionality at the 2-position. This combination imparts enhanced electron-withdrawing character and improved solubility in polar solvents, enabling efficient integration into bioactive scaffolds for medicinal chemistry applications under standard bench conditions.

Application

6-(Trifluoromethyl)imidazo[1,2-a]pyrazine-2-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling the construction of bioactive scaffolds through standard amide coupling and derivatization protocols. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid functionality facilitates direct conjugation or salt formation. Bench-stable and compatible with common synthetic workflows, it functions effectively in both solution-phase and solid-phase synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   67.49
  • LogP   1.4463
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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