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CS-W001157 4
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1-Methyl-1H-imidazole-4-sulfonyl chloride

  • CAS No. 137049-00-4

  • Cat. No. CS-0074849
  • Molecule weight180.61
  • Purity≥97%
  • MDL No.MFCD00068060

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-imidazole-4-sulfonyl chloride|CS-0074849

Structure of 137049-00-4

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General Information

  • CAS No. 137049-00-4
  • Cat. No. CS-0074849
  • Purity ≥97%
  • MDL No. MFCD00068060
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅ClN₂O₂S
  • Molecular Weight 180.61
  • Synonym(s) 1-METHYLIMIDAZOLE-4-SULFONYL CHLORIDE
  • SMILES O=S(C1=CN(C)C=N1)(Cl)=O

Description

1-Methyl-1H-imidazole-4-sulfonyl chloride is a bench-stable, moisture-tolerant sulfonyl chloride reagent featuring a sterically accessible sulfonamide handle. This electrophilic moiety integrates readily into synthetic scaffolds under mild conditions, enabling efficient derivatization of nucleophiles such as amines and alcohols. The electron-deficient imidazole ring enhances reactivity while maintaining compatibility with diverse functional groups.

Application

1-Methyl-1H-imidazole-4-sulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of the 1-methyl-1H-imidazol-4-ylsulfonyl group into diverse substrates. Its reactivity enables selective sulfonation of nucleophiles such as amines and alcohols under mild conditions, offering high functional group tolerance and ease of purification. The imidazole scaffold provides enhanced stability and solubility, making it well-suited for applications in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   51.96
  • LogP   0.3476
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   1

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