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Structure of 137-64-4
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2-Chloro-5-(chlorosulfonyl)benzoic acid features a dual functionalization pattern with a chlorosulfonyl group and carboxylic acid moiety positioned ortho to each other on the aromatic ring. This configuration enables direct incorporation into sulfonamide couplings or derivatization via nucleophilic substitution, offering a streamlined route to bioactive sulfonated compounds. The molecule exhibits enhanced reactivity under mild conditions due to the electron-withdrawing influence of the chlorosulfonyl group adjacent to the carboxylic acid.
2-Chloro-5-(chlorosulfonyl)benzoic acid serves as a versatile building block for sulfonamide and sulfonic acid derivatives, enabling efficient functionalization in heterocyclic synthesis. Its orthogonal reactivity profile—combining a carboxylic acid with a highly electrophilic chlorosulfonyl group—facilitates selective transformations under mild conditions. The molecule exhibits excellent bench stability and compatibility with common protecting groups, making it ideal for iterative synthetic sequences in medicinal chemistry and process development workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: