Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1,3-Difluoro-2-iodobenzene

  • CAS No. 13697-89-7

  • Cat. No. CS-0059149
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,3-Difluoro-2-iodobenzene|CS-0059149

Structure of 13697-89-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 13697-89-7
  • Cat. No. CS-0059149
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂I
  • Molecular Weight 239.99
  • Synonym(s) 2,6-Difluoroiodobenzene
  • SMILES IC1=C(F)C=CC=C1F

Description

1,3-Difluoro-2-iodobenzene is a fluorinated aryl iodide featuring complementary halogen substitution patterns that enable selective cross-coupling reactions. The ortho-iodo group facilitates palladium-catalyzed transformations, while the difluoro substitution enhances electronic tuning and metabolic stability. This molecule serves as a key intermediate in the synthesis of bioactive heterocycles and functionalized aromatic scaffolds.

Application

1,3-Difluoro-2-iodobenzene serves as a versatile aryl building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted biaryls and heterocycles. The ortho-iodo group facilitates palladium-catalyzed coupling with high regioselectivity, while the difluoro substitution enhances metabolic stability and modulates electronic properties—making it valuable for medicinal chemistry and materials synthesis. Bench-stable and readily purified, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1
    • null|null
      372-18-9
    • ~98%
    • In-stock
      1,3-Difluoro-2-iodobenzene|CS-0059149
      13697-89-7

    References

    • Rausis, Thierry; Schlosser, Manfred European Journal of Organic Chemistry, 2002 , # 19 p. 3351 - 3358
  • Route2

    References

    • WO2006/113471 A2, ; Page/Page column 51-52 ; WO 2006/113471 A2
  • Route3
    • Benzene, 1,3-difluoro-2-(trimethylsilyl)-|CS-0723260
      133117-48-3
    • ~68%
    • In-stock
      1,3-Difluoro-2-iodobenzene|CS-0059149
      13697-89-7

    References

    • Bennetau, Bernard; Rajarison, Florent; Dunogues, Jacques; Babin, Pierre Tetrahedron, 1993 , vol. 49, # 47 p. 10843 - 10854

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   0
  • LogP   2.5694
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 1,3-Difluoro-2-iodobenzene sigma1,3-Difluoro-2-iodobenzene manufacturer1,3-Difluoro-2-iodobenzene price1,3-Difluoro-2-iodobenzene structure1,3-Difluoro-2-iodobenzene SDSbuy 1,3-Difluoro-2-iodobenzene1,3-Difluoro-2-iodobenzene supplier1,3-Difluoro-2-iodobenzene uses1,3-Difluoro-2-iodobenzene molecular weightprice of 1,3-Difluoro-2-iodobenzene1,3-Difluoro-2-iodobenzene chemical name formula of 1,3-Difluoro-2-iodobenzene
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label