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Structure of 136888-20-5
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5-Fluoro-3-nitropyridin-2(1H)-one features a fused heterocyclic core with orthogonal electron-withdrawing groups: a fluorine atom at the 5-position and a nitro group at the 3-position. This combination imparts strong electron deficiency, enhancing reactivity in nucleophilic substitution and enabling direct functionalization at the pyridone ring. The molecule exhibits bench-stable behavior under standard conditions, facilitating straightforward handling in synthetic workflows.
5-Fluoro-3-nitropyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling the construction of nitrogen-containing heterocycles via palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its fluorine and nitro groups provide orthogonal reactivity for sequential functionalization, while the pyridinone core offers enhanced solubility and metabolic stability. The compound exhibits bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: