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Structure of 1368466-66-3
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1-Cyclopropyl-1H-imidazole-4-carboxylic acid features a cyclopropyl group attached to the imidazole ring, enhancing lipophilicity and metabolic stability. This scaffold integrates readily into bioactive molecules, offering a rigid, electron-rich platform for medicinal chemistry applications. The carboxylic acid moiety enables direct conjugation or salt formation, facilitating solubility tuning and downstream derivatization in drug discovery workflows.
1-Cyclopropyl-1H-imidazole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of imidazole-based scaffolds with enhanced metabolic stability. Its carboxylic acid functionality facilitates direct coupling reactions and derivatization under standard amide bond formation conditions. The cyclopropyl substituent imparts favorable lipophilic character and conformational rigidity, contributing to improved target binding affinity. Bench-stable and readily purified by recrystallization, it functions reliably in high-throughput screening campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: