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CS-W001157 4
Total: USD 88.00

3-Methoxypyrrolidine hydrochloride

  • CAS No. 136725-50-3

  • Cat. No. CS-W004880
  • Purity≥97%
  • MDL No.MFCD09261403

*For research and further manufacturing use only, not for direct human use.

3-Methoxypyrrolidine hydrochloride|CS-W004880

Structure of 136725-50-3

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General Information

  • CAS No. 136725-50-3
  • Cat. No. CS-W004880
  • Purity ≥97%
  • MDL No. MFCD09261403
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO
  • Molecular Weight 137.61
  • Synonym(s) 3-Methoxy-Pyrrolidine Hydrochloride
  • SMILES COC1CNCC1.[H]Cl

Description

3-Methoxypyrrolidine hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring a methoxy group at the 3-position. This configuration enhances solubility and modulates basicity, enabling efficient incorporation into medicinal chemistry libraries. The salt form ensures improved handling and compatibility in synthetic workflows.

Application

3-Methoxypyrrolidine hydrochloride serves as a versatile nitrogen-containing heterocyclic building block in medicinal chemistry, enabling efficient access to pyrrolidine-based pharmacophores. Its bench-stable hydrochloride salt form facilitates handling and purification, while the methoxy group provides a polar, electron-donating substituent that enhances solubility and modulates reactivity in amide couplings, alkylation reactions, and transition-metal-catalyzed transformations.

Synthesis

  • Route1
    • tert-Butyl 3-methoxypyrrolidine-1-carboxylate|CS-0079175
      146257-03-6
    • ~%
    • In-stock
      3-Methoxypyrrolidine hydrochloride|CS-W004880
      136725-50-3

    References

    • US2007/78147 A1, ; Page/Page column 77 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.4165
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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