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CS-W001157 4
Total: USD 88.00

Allyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-threoninate

  • CAS No. 136523-92-7

  • Cat. No. CS-0361179
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Allyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-threoninate|CS-0361179

Structure of 136523-92-7

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General Information

  • CAS No. 136523-92-7
  • Cat. No. CS-0361179
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₃NO₅
  • Molecular Weight 381.42
  • Synonym(s) N-Fmoc-L-threonine Allyl Ester
  • SMILES C=CCOC([C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)[C@H](O)C)=O

Description

Allyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-threoninate is a protected amino acid derivative featuring a fluorenylmethyl carbamate (Fmoc) group and an allyl ester moiety. This dual protection enables orthogonal handling in peptide synthesis, where the Fmoc group facilitates base-labile deprotection and the allyl ester allows for selective removal via palladium-catalyzed cleavage. The molecule integrates seamlessly into solid-phase workflows, offering high stability under standard conditions and compatibility with diverse coupling protocols.

Synthesis

  • Route1
    • In-stock
      Fmoc-Thr-OH|CS-W009412
      73731-37-0
    • null|null
      106-95-6
    • ~96%
    • In-stock
      Allyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-threoninate|CS-0361179
      136523-92-7

    References

    • Wojnar, Joanna M.; Evans, Clive W.; Devries, Arthur L.; Brimble, Margaret A. Australian Journal of Chemistry, 2011 , vol. 64, # 6 p. 723 - 731
  • Route2
    • null|null
      612490-86-5
    • ~81%
    • In-stock
      Allyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-threoninate|CS-0361179
      136523-92-7

    References

    • Marcinkowska; Borovickova; Slaninova; Grzonka Polish Journal of Chemistry, 2007 , vol. 81, # 7 p. 1335 - 1344
  • Route3

    References

    • Tetrahedron Letters, , vol. 52, # 22 p. 2808 - 2811

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   3.0037
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   7

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