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Structure of 1095952-22-9
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Fmoc-Gly-Ser(psi(Me,Me)pro)-OH is a conformationally constrained serine derivative featuring a rigid psi(Me,Me)pro linkage that locks the peptide backbone in a defined turn geometry. This structural rigidity enhances target binding affinity and proteolytic stability, making it ideal for peptidomimetic design and solid-phase synthesis of bioactive sequences requiring precise spatial orientation.
Fmoc-Gly-Ser(ψ(Me,Me)Pro)-OH serves as a key building block for the synthesis of constrained peptide scaffolds, leveraging the rigid bicyclic proline mimic to stabilize bioactive conformations. The ψ(Me,Me)Pro residue enhances proteolytic resistance and conformational preorganization, while the Fmoc group enables efficient solid-phase peptide synthesis. Bench-stable and compatible with standard coupling protocols, this derivative facilitates the construction of complex cyclic peptides and peptidomimetics with improved metabolic stability and target affinity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: