tert-Butyl N-[(3R,5R)-5-fluoropiperidin-3-yl]carbamate

Name: tert-Butyl N-[(3R,5R)-5-fluoropiperidin-3-yl]carbamate
Brand: ChemScene
Availability: InStock
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CAS No. 1363378-07-7
Cat. No. CS-0048000
Purity≥98%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl N-[(3R,5R)-5-fluoropiperidin-3-yl]carbamate|CS-0048000

Structure of 1363378-07-7

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Description

tert-Butyl N-[(3R,5R)-5-fluoropiperidin-3-yl]carbamate is a chiral piperidine derivative featuring a fluorine atom at the 5-position and a bench-stable tert-butyl carbamate protecting group. This configuration enables selective incorporation into complex scaffolds, particularly in medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors. The stereochemistry enhances binding affinity and metabolic stability in bioactive analogs.

Application

tert-Butyl N-[(3R,5R)-5-fluoropiperidin-3-yl]carbamate serves as a stereochemically defined, bench-stable building block for the synthesis of fluorinated piperidine scaffolds. The protected amine enables selective functionalization at the 3-position while maintaining configurational integrity during downstream transformations. Its compatibility with standard coupling reactions and ease of deprotection under mild acidic conditions facilitates integration into complex molecular architectures, including bioactive heterocycles and pharmaceutical intermediates.

General Information

CAS No. 1363378-07-7
Cat. No. CS-0048000
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₉FN₂O₂
Molecular Weight 218.27
Synonym(s) tert-Butyl ((3R,5R)-5-fluoropiperidin-3-yl)carbamate
SMILES CC(C)(C)OC(=O)N[C@H]1CNC[C@H](F)C1

Computational Chemistry Data

TPSA 50.36
LogP 1.2111
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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tert-Butyl N-[(3R,5R)-5-fluoropiperidin-3-yl]carbamate

CAS No. 1363378-07-7

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