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CS-W001157 4
Total: USD 88.00

3,5-Dibromo-4-chloropyridine

  • CAS No. 13626-17-0

  • Cat. No. CS-W021808
  • Purity≥98%
  • MDL No.MFCD00233993

*For research and further manufacturing use only, not for direct human use.

3,5-Dibromo-4-chloropyridine|CS-W021808

Structure of 13626-17-0

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General Information

  • CAS No. 13626-17-0
  • Cat. No. CS-W021808
  • Purity ≥98%
  • MDL No. MFCD00233993
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Br₂ClN
  • Molecular Weight 271.34
  • Synonym(s) 4-Chloro-3,5-dibroMopyridine
  • SMILES ClC1=C(Br)C=NC=C1Br

Description

Polyphosphoric acid is used as a dehydrating agent, cyclizing agent, acylating agent, analytical reagent and as a ring closing reagent. It is used in the production of phosphate esters, acid phosphates and pharmaceuticals. It is involved in metal treatment and as an asphalt and a bitumen additive. Furthermore, it is employed for the determination of tryptophan and used a reagent for the alkylation and acylation reactions of aromatic and alkenic compounds.

Application

3,5-Dibromo-4-chloropyridine serves as a versatile building block in heterocyclic synthesis, enabling regioselective functionalization via palladium-catalyzed cross-coupling reactions. The ortho-bromine and chlorine substituents provide complementary reactivity for sequential derivatization, while the pyridine core offers stability and compatibility with standard synthetic workflows. Its bench-stable nature and predictable transformation profile make it ideal for constructing complex scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Pichowicz, Mark; Crumpler, Simon; McDonald, Edward; Blagg, Julian Tetrahedron, 2010 , vol. 66, # 13 p. 2398 - 2403
  • Route2

    References

    • Zhang, Yuan; Zhang, Yong; Sun, Ya Lei; Du, Xin; Shi, Jiao Yi; Wang, Wei; Wang, Wei David Chemistry - A European Journal, 2012 , vol. 18, # 20 p. 6328 - 6334
  • Route3
    • Pyridin-4(1H)-one|CS-0166783
      108-96-3
    • ~%
    • In-stock
      3,5-Dibromo-4-chloropyridine|CS-W021808
      13626-17-0

    References

    • Journal of Organic Chemistry, , vol. 65, # 10 p. 3154 - 3159

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.26
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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