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CS-W001157 4
Total: USD 88.00

4-Amino-3,5-dibromopyridine

  • CAS No. 84539-34-4

  • Cat. No. CS-W002549
  • Purity≥98%
  • MDL No.MFCD00234048

*For research and further manufacturing use only, not for direct human use.

4-Amino-3,5-dibromopyridine|CS-W002549

Structure of 84539-34-4

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General Information

  • CAS No. 84539-34-4
  • Cat. No. CS-W002549
  • Purity ≥98%
  • MDL No. MFCD00234048
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄Br₂N₂
  • Molecular Weight 251.91
  • Synonym(s) 4-Pyridinamine, 3,5-dibromo-
  • SMILES NC1=C(Br)C=NC=C1Br

Description

4-Amino-3,5-dibromopyridine features a pyridine core functionalized with bromine atoms at the 3 and 5 positions and an amino group at the 4 position, enabling selective coupling reactions. This electron-deficient heterocycle integrates readily into cross-coupling workflows, serving as a key intermediate in the synthesis of bioactive nitrogen-containing scaffolds.

Application

4-Amino-3,5-dibromopyridine serves as a versatile building block for the synthesis of functionalized heterocycles and pharmaceutical intermediates. The amino group enables nucleophilic substitution or coupling reactions, while the dibromo substitution pattern supports sequential cross-coupling strategies. Its bench-stable nature and compatibility with Pd-catalyzed transformations facilitate efficient construction of complex scaffolds in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      504-24-5
    • ~94%
    • In-stock
      4-Amino-3,5-dibromopyridine|CS-W002549
      84539-34-4

    References

    • Zhang, Yuan; Zhang, Yong; Sun, Ya Lei; Du, Xin; Shi, Jiao Yi; Wang, Wei; Wang, Wei David Chemistry - A European Journal, 2012 , vol. 18, # 20 p. 6328 - 6334
  • Route2
    • null|null
      504-24-5
    • ~10%
    • In-stock
      4-Amino-3-bromopyridine|CS-W002872
      13534-98-0
    • In-stock
      4-Amino-3,5-dibromopyridine|CS-W002549
      84539-34-4

    References

    • Synthesis, , # 14 p. 2175 - 2179
  • Route3
    • null|null
      62516-09-0
    • ~%
    • In-stock
      4-Amino-3,5-dibromopyridine|CS-W002549
      84539-34-4

    References

    • Recueil des Travaux Chimiques des Pays-Bas, , vol. 72, p. 296,298

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.1888
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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