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CS-W001157 4
Total: USD 88.00

1,2,3,4-Tetrahydro-1,7-naphthyridine

  • CAS No. 13623-86-4

  • Cat. No. CS-0099940
  • Purity≥98%
  • MDL No.MFCD11506143

*For research and further manufacturing use only, not for direct human use.

1,2,3,4-Tetrahydro-1,7-naphthyridine|CS-0099940

Structure of 13623-86-4

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General Information

  • CAS No. 13623-86-4
  • Cat. No. CS-0099940
  • Purity ≥98%
  • MDL No. MFCD11506143
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂
  • Molecular Weight None
  • Synonym(s) 1,2,3,4-Tetrahydro-1,7-naphthyridin
  • SMILES C12=CC=NC=C1NCCC2

Description

1,2,3,4-Tetrahydro-1,7-naphthyridine features a saturated pyridine ring fused to a benzene moiety, delivering a rigid, electron-rich heterocyclic scaffold. This bench-stable core integrates readily into medicinal chemistry libraries, offering enhanced solubility and metabolic stability in bioactive molecule design.

Application

1,2,3,4-Tetrahydro-1,7-naphthyridine serves as a versatile heterocyclic building block in medicinal chemistry, offering a rigid, nitrogen-rich scaffold with defined basicity and hydrogen-bonding capacity. Its stability under standard synthetic conditions enables reliable functionalization at the 1- and 7-positions, facilitating coupling reactions and derivatization for target-oriented synthesis. The compound functions effectively as a core motif in kinase inhibitor development and exhibits favorable handling properties for bench-scale applications.

Synthesis

  • Route1
    • 1,7-Naphthyridine|CS-0782218
      253-69-0
    • ~%
    • 5,6,7,8-Tetrahydro-1,7-naphthyridine|CS-0043676
      13623-85-3
    • In-stock
      1,2,3,4-Tetrahydro-1,7-naphthyridine|CS-0099940
      13623-86-4

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 6, p. 408,411 Journal of the Chemical Society [Section] C: Organic, , p. 377
  • Route2
    • 4-Hydrazinyl-1,7-naphthyridine|CS-1666239
      99584-25-5
    • ~%
    • In-stock
      1,2,3,4-Tetrahydro-1,7-naphthyridine|CS-0099940
      13623-86-4

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 6, p. 408,411
  • Route3
    • 1,7-Naphthyridine|CS-0782218
      253-69-0
    • null|null
      64-17-5
    • ~%
    • 5,6,7,8-Tetrahydro-1,7-naphthyridine|CS-0043676
      13623-85-3
    • In-stock
      1,2,3,4-Tetrahydro-1,7-naphthyridine|CS-0099940
      13623-86-4

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 6, p. 408,411 Journal of the Chemical Society [Section] C: Organic, , p. 377

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H318-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   1.4397
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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