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Structure of 1360952-35-7
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Methyl 6-chloro-5-(trifluoromethyl)nicotinate features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability. The chloro substituent at the 6-position enables selective functionalization in late-stage diversification. This bench-stable ester integrates readily into synthetic routes for bioactive heterocycles, offering improved solubility and reactivity under standard conditions.
Methyl 6-chloro-5-(trifluoromethyl)nicotinate serves as a versatile building block in medicinal chemistry, enabling direct incorporation of both chloro and trifluoromethyl groups into heterocyclic scaffolds. The ester functionality facilitates downstream transformations, while the electron-deficient pyridine core supports palladium-catalyzed cross-coupling reactions. Bench-stable and compatible with standard purification methods, it functions as a key intermediate in the synthesis of bioactive nitrogen-containing compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P264-P270-P330
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Lot numbers can be found on the outside label of a product: