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CS-W001157 4
Total: USD 88.00

7-Bromo-1H-indole-6-carboxylic acid

  • CAS No. 1360921-60-3

  • Cat. No. CS-0200234
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-1H-indole-6-carboxylic acid|CS-0200234

Structure of 1360921-60-3

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General Information

  • CAS No. 1360921-60-3
  • Cat. No. CS-0200234
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆BrNO₂
  • Molecular Weight 240.05
  • Synonym(s) None
  • SMILES O=C(C1=C(Br)C2=C(C=C1)C=CN2)O

Description

7-Bromo-1H-indole-6-carboxylic acid features a bromine substituent at the 7-position and a carboxylic acid group at the 6-position of the indole core. This configuration enables direct coupling in amide bond formation, supporting efficient access to bioactive scaffolds. The electron-deficient nature of the ring enhances reactivity in transition metal-catalyzed transformations.

Application

7-Bromo-1H-indole-6-carboxylic acid serves as a versatile building block for the synthesis of biologically active indole derivatives. Its bromo and carboxylic acid functionalities enable palladium-catalyzed cross-coupling reactions and direct amidation, facilitating the construction of pharmaceutical scaffolds. The compound exhibits good bench stability and is readily purified by recrystallization, supporting its use in iterative synthetic sequences and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.6286
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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