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CS-W001157 4
Total: USD 88.00

Tert-butyl (S)-(1-cyclopropyl-2-hydroxyethyl)carbamate

  • CAS No. 1360774-41-9

  • Cat. No. CS-0138437
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tert-butyl (S)-(1-cyclopropyl-2-hydroxyethyl)carbamate|CS-0138437

Structure of 1360774-41-9

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General Information

  • CAS No. 1360774-41-9
  • Cat. No. CS-0138437
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₃
  • Molecular Weight 201.26
  • Synonym(s) TERT-BUTYL N-[(1S)-1-CYCLOPROPYL-2-HYDROXYETHYL]CARBAMATE
  • SMILES O=C(OC(C)(C)C)N[C@@H](C1CC1)CO

Description

Tert-butyl (S)-(1-cyclopropyl-2-hydroxyethyl)carbamate is a chiral protecting group reagent featuring a stereodefined hydroxyl-bearing side chain. This bench-stable carbamate delivers selective protection for primary amines in complex synthesis, enabling straightforward deprotection under mild acidic conditions. The cyclopropyl moiety imparts enhanced rigidity and stereochemical integrity, making it ideal for asymmetric synthesis workflows requiring high enantiomeric fidelity.

Application

Tert-butyl (S)-(1-cyclopropyl-2-hydroxyethyl)carbamate serves as a chiral auxiliary for asymmetric synthesis, enabling stereoselective transformations via its stable hydroxyl and carbamate functionalities. The cyclopropyl group enhances conformational rigidity, improving stereocontrol in nucleophilic additions and reductions. Bench-stable and readily purified by flash chromatography, it functions effectively in peptide coupling and heterocycle construction workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   1.282
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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