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CS-W001157 4
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1-Methyl-1h-indol-6-amine

  • CAS No. 135855-62-8

  • Cat. No. CS-0207940
  • Purity≥98%
  • MDL No.MFCD10000822

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1h-indol-6-amine|CS-0207940

Structure of 135855-62-8

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General Information

  • CAS No. 135855-62-8
  • Cat. No. CS-0207940
  • Purity ≥98%
  • MDL No. MFCD10000822
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀N₂
  • Molecular Weight 146.19
  • Synonym(s) 6-Amino-1-methylindole
  • SMILES CN1C=CC2=C1C=C(C=C2)N

Description

1-Methyl-1H-indol-6-amine features a methylated indole core with a primary amine at the 6-position, delivering enhanced solubility and stability compared to unsubstituted analogs. This electron-rich scaffold integrates readily into bioactive molecule design, serving as a key building block for pharmaceuticals and functional materials.

Application

1-Methyl-1H-indol-6-amine serves as a versatile building block in medicinal chemistry, enabling rapid access to substituted indole scaffolds through electrophilic substitution and cross-coupling reactions. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of heterocyclic libraries and API intermediates.

Synthesis

  • Route1

    References

    • Coullet, Fabien; Morel, Sandrine; Boyer, Gerard; Galy, Jean Pierre Synthetic Communications, 1998 , vol. 28, # 1 p. 147 - 157
  • Route2

    References

    • Synthetic Communications, , vol. 28, # 1 p. 147 - 157

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.95
  • LogP   1.7605
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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