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CS-W001157 4
Total: USD 88.00

2-bromo-6-methoxypyridin-3-amine

  • CAS No. 135795-46-9

  • Cat. No. CS-W000812
  • Purity≥98%
  • MDL No.MFCD05662394

*For research and further manufacturing use only, not for direct human use.

2-bromo-6-methoxypyridin-3-amine|CS-W000812

Structure of 135795-46-9

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General Information

  • CAS No. 135795-46-9
  • Cat. No. CS-W000812
  • Purity ≥98%
  • MDL No. MFCD05662394
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂O
  • Molecular Weight 203.04
  • Synonym(s) 2-bromo-6-methoxypyridin-3-amine
  • SMILES COc1ccc(N)c(Br)n1

Description

3-Amino-2-bromo-6-methoxypyridine features a pyridine core functionalized with amino, bromo, and methoxy groups at strategic positions. This electron-deficient heterocycle enables direct coupling reactions in cross-coupling protocols. The ortho-bromo substituent facilitates palladium-catalyzed transformations, while the amino and methoxy groups offer orthogonal reactivity for downstream derivatization. Bench-stable under standard conditions, it serves as a key building block in medicinal chemistry and agrochemical synthesis.

Application

3-Amino-2-bromo-6-methoxypyridine serves as a versatile building block for the synthesis of functionalized pyridine derivatives. The amino and bromo groups enable sequential cross-coupling reactions, while the methoxy substituent enhances solubility and modulates electronic properties. This compound exhibits good bench stability and facilitates efficient derivatization in medicinal chemistry and agrochemical research.

Synthesis

  • Route1

    References

    • LABORATOIRES FOURNIER S.A. Patent: US2008/200495 A1, 2008 ; Location in patent: Page/Page column 9 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.4349
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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