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Structure of 1357281-69-6
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4-Ethynyl-3-methylbenzoic acid features a conjugated alkyne group flanked by electron-rich aromatic and methyl substituents, enabling efficient copper-catalyzed coupling reactions. This bench-stable, moisture-tolerant reagent integrates readily into bioconjugation workflows and modular synthesis platforms, delivering high functional group compatibility and clean reaction profiles under standard conditions.
4-Ethynyl-3-methylbenzoic acid serves as a versatile building block for constructing functionalized aromatic scaffolds via palladium-catalyzed coupling reactions. The conjugated alkyne and carboxylic acid functionalities enable efficient derivatization through Sonogashira coupling, esterification, or amide formation, while the methyl group provides moderate steric and electronic modulation. Bench-stable and readily purified by recrystallization, it facilitates streamlined synthesis of bioactive molecules and advanced intermediates in medicinal chemistry and materials science.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: