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tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate

  • CAS No. 1356476-27-1

  • Cat. No. CS-0048458
  • Purity≥98%
  • MDL No.MFCD20926183

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate|CS-0048458

Structure of 1356476-27-1

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General Information

  • CAS No. 1356476-27-1
  • Cat. No. CS-0048458
  • Purity ≥98%
  • MDL No. MFCD20926183
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₅NO₃
  • Molecular Weight 255.36
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC2(CC1)CC(CO)C2

Description

tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate features a spirocyclic scaffold with a pendant hydroxymethyl group, enabling direct functionalization for synthetic diversification. The tert-butyl ester enhances stability and solubility in organic media, while the nitrogen-rich framework supports incorporation into complex heterocycles. This bench-stable intermediate facilitates efficient access to bioactive alkaloid analogs and medicinal chemistry libraries.

Application

tert-Butyl 2-(hydroxymethyl)-7-azaspiro[3.5]nonane-7-carboxylate serves as a versatile spirocyclic building block for medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles. The pendant hydroxymethyl group facilitates selective functionalization, while the tert-butyl ester supports orthogonal deprotection under mild acidic conditions. Its rigid spiro scaffold enhances conformational control in target molecule design, and the compound exhibits excellent bench stability and compatibility with standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.406
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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